CD14分子
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CD14 分子
CD14
常用单克隆抗体或代号：Mo2,UCHM1,LeuM3,MY4
主要表达细胞：M,G,DC,LHC [M]
分子质量(kDa)和结构：gp55(GPI连接)
功 能：LPS/LBP复合体受体
CD14
Aka lipopolysaccharide (LPS) receptor, endotoxin receptor
Binding of LPS to CD14 on macrophages causes their activation and release of cytokines
Involved in the clearance of apoptotic cells
Also regulates IgE levels
Positive staining (normal): macrophages/monocytes (90%), granulocytes-weak (30%), Langerhans cells; dendritic cells, B cells
Positive staining (disease): B-CLL (90%), follicular center cell lymphoma (80%), diffuse large B cell lymphoma (40%); AML-M4/M5 (50-90%)
Negative staining: myeloid progenitors, AML M3, M6, M7, M0-M2 (usually)
