Synthesis of Peptides Using Tert-Butyloxycarbonyl (Boc) as the -Amino Protection Group
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The use of the tert -butyloxycarbonyl (Boc) as the N α-amino protecting group in peptide synthesis can be advantageous in several cases, such as synthesis of hydrophobic peptides and peptides containing ester and thioester moieties. The primary challenge of using Boc SPPS is the need for treatment of the resin-bound peptide with hazardous hydrogen fluoride (HF), which requires special equipment.
![N-[2-[4-[[6-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethyl]-2-azaspiro[3.3]heptan-2-yl]methyl]cyclohexyl]-5-(2-hydroxypropan-2-yl)-1,3-benzothiazol-6-yl]-6-(trifluoromethyl)pyridine-2-carboxamide，Moligand™，阿拉丁](https://img1.dxycdn.com/p/s14/2024/0619/785/8670042233826733081.jpg!wh200)
![(2S,4S)-tert-butyl 2-(tert-butoxycarbonylamino)-5-oxo-4-(tosyloxy)-5-(2,4,6-trimethoxybenzylamino)pentanoate;(2S,4S)-2-(Boc-氨基)-5-氧代-4-(对甲苯基磺酰基氧基)-5-[(2,4,6-三甲氧基苄基)氨基]戊酸叔丁酯](https://img1.dxycdn.com/p/s14/2025/1009/171/0405943971658126791.jpg!wh200)
