• 我要登录|
  • 免费注册
    |
  • 我的丁香通
    • 企业机构:
    • 成为企业机构
    • 个人用户:
    • 个人中心
  • 移动端
    移动端
丁香通 logo丁香实验_LOGO
搜实验

    大家都在搜

      大家都在搜

        0 人通过求购买到了急需的产品
        免费发布求购
        发布求购
        点赞
        收藏
        wx-share
        分享

        Immunological Characterization

        互联网

        590
        As part of the assessment of product consistency and putative potency, it is often necessary to check not only that a vaccine contains the desired antigens, but also that they are in the correct immunological form (see Note 1 ). In general, this immunological characterization of a vaccine is interpreted as the ability of the preparation to invoke an appropriate immune response to its major constitutent antigens. The immune response in question may be in the form of serum antibodies, secretory antibodies, cell-mediated immunity (CMI), or a combination of these. The best approach to characterization of the immune response may be qualitative, such as immunoblotting to check for the presence of antibodies to specific antigens (1 ), quantitative, such as immunosorbent assays to measure the level of the antibody response to a particular antigen (2 ), or functional, such as toxin neutralization (3 ) to assess the magnitude of the functional activity of the response. The nature of the vaccine to be characterized and how its protective efficacy is mediated must be considered when deciding which aspects of the immune response should be examined and how they will be assessed.
        ad image
        提问
        扫一扫
        丁香实验小程序二维码
        实验小助手
        丁香实验公众号二维码
        扫码领资料
        反馈
        TOP
        打开小程序