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        Detection of K-ras Point Mutations in Sputum from Patients with Adenocarcinoma of the Lung by Point-EXACCT

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        Lung cancer is a disease with high incidence and mortality (1 ). The prognosis for patients with lung cancer is most favorable when tumors are detected early in a surgically resectable stage of non-small cell lung cancer (NSCLC). Methods that can increase the percentage of cases of lung cancer detected in early stage may theoretically lead to a decrease in mortality. However, in the past, screening programs for early detection of lung cancer that used chest X-ray of the thorax with or without sputum cytology have not been successful in reducing the high numbers of lung cancer deaths (2 5 ). Therefore, new approaches that use genetic alterations as potential biomarkers may be beneficial for early detection.
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