EWS Gene Fusions as Diagnostic Markers in Sarcomas: Principles and Guidelines
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| Chromosomal translocatron | Fusion product | EWS forward primera | Reverse primer | Product size (bp) | Internal and fusion Junction probes | 
|---|---|---|---|---|---|
| Ewmg’s sarcoma/PNET | |||||
| t(ll.22)(q24,q12) | EWS/FLII | ex 7 | FLII ex 9 ACTCCCCGTTGGTCCCCTCC | type1 120 | EWS ex 7 TATAGCCAACAGAGGAGCAG | 
| type2 183 | FL11 ex 6 CAAGCTCCTCTTCTGACTGAG | ||||
| ex 7 | FLII ex 6 GITGAGGCCAGAATTCATGTTA | type1 327 | EWS/FLII type1 ACGGGCAGCAGAACCCTTCTTATG | ||
| type 2 390 | EWS/FLII type 2 ACGGGCAGCAGAGTTCACTGCTGG | ||||
| t(21,22)(q22,q12) | EWS/ERG | ex 7 | ERG ex 9 AAAGCTGGATCTGGCCACTG | Various | ERG AGTCGAAAGCTGCTCACCATCT | 
| Clear-cell sarcoma (MMSP) | |||||
| t(l2,22)(q13,q12) | EWS/ATFI | ex 8 | ATFI TCTCCGTCTCCTTTTCTGC | 126 | EWS/ATFI CGGTGGAATGGGAAAAATTTTGAA | 
| Desmoplastlc SRCT | |||||
| t(12,22)(pl3,q12) | EWS/WTI | ex 7 | WTI ex 9 GACCAGGAGAACTTKGCTGAC | 197 | EWS/WTI ACGGGCAGCAGAGTGAGAAACCAT | 
| Extraskeletal myxold CS | |||||
| t(9,22)(q22,ql2) | EWS/CHN | ||||
| type 1 | ex 12 | CHN CCTGGAGGGGAAGGGCTAT | 109 | EWS/CHN type 1 AATGGTTTGATGATATGCCCTGCG | |
| type 2 | ex 7 | CHN CCTGGAGGGGAAGGGCTAT | 275 | EWSKHN type 2 ACGGGCAGCAGAAGCCCACTGCGG | 











