• 我要登录|
  • 免费注册
    |
  • 我的丁香通
    • 企业机构:
    • 成为企业机构
    • 个人用户:
    • 个人中心
  • 移动端
    移动端
丁香通 logo丁香实验_LOGO
搜实验

    大家都在搜

      大家都在搜

        0 人通过求购买到了急需的产品
        免费发布求购
        发布求购
        点赞
        收藏
        wx-share
        分享

        Antigen Uptake by Dendritic Cells

        互联网

        659
        Newly generated dendritic cells (DC) migrate from the bone marrow to the nonlymphoid tissues presumably through the blood stream (peripheral blood DC). During injury, tissue DC (such as Langerhans cells [LC] in the epidermis) capture antigen and then, under microenvironmental signals, leave the nonlymphoid tissues through the afferent lymph as veiled cells ( see Fig. 1 ). During their migration, DC undergo maturation, including loss of antigen uptake and acquisition of costimulatory function. Then, DC enter into lymph nodes where they home to the T-cell rich area (inderdigitating cells) and induce an antigen specific primary T-cell response.
        Fig. 1.  Life cycle of dendritic cells. Newly generated dendritic cells migrate, from the bone marrow to the nonlymphoid tissues presumably through the blood stream (peripheral blood DC). During an injury, tissue dendritic cells (such as LC in the epidermis) capture the antigen and then, under microenvironmental signals (such as TNFα production in the dermis) leave the nonlymphoid tissues through the afferent lymph (veiled cells). During their migration, DC undergo maturation, including loss of antigen uptake and aquisition of costimulatory function. Then, DC enter into lymph nodes where they home to the T-cell rich area (interdigitating cells) and induce an antigen specific primary T-cell response. Few DC exit lymph nodes possibly because they may either be programmed to die after antigen presentation or destroyed by the afferent immune response.

        ad image
        提问
        扫一扫
        丁香实验小程序二维码
        实验小助手
        丁香实验公众号二维码
        扫码领资料
        反馈
        TOP
        打开小程序