Construction of VNP20009: A Novel, Genetically Stable Antibiotic-Sensitive Strain of Tumor-Targeting Salmonella for Parenteral Administration in Human
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The engineering of tumor-targeting Salmonella strains bearing a high degree of both attenuation and tumor inhibition is a recently developed approach to vector-based treatment of cancer (1 ,2 ). Tumor-targeted Salmonella have many desirable features for a tumor-selective delivery vehicle:
