• 我要登录|
  • 免费注册
    |
  • 我的丁香通
    • 企业机构:
    • 成为企业机构
    • 个人用户:
    • 个人中心
  • 移动端
    移动端
丁香通 logo丁香实验_LOGO
搜实验

    大家都在搜

      大家都在搜

        0 人通过求购买到了急需的产品
        免费发布求购
        发布求购
        点赞
        收藏
        wx-share
        分享

        Antisense Oligonucleotide Approach to Study NPY-Mediated Feeding Signal Transduction

        互联网

        715
        Antisense oligodeoxynucleotides have been successfully employed to study the function of viral and cellular genes by sequence-specific inhibition. The antisense oligodeoxynucleotides are single-stranded, short, native, or chemically modified nucleotides that inhibit individual gene expression by selective complementary base pairing. These antisense compounds that inhibit gene expression can be grouped into two classes: (1) those leading to a reduction in target RNA levels, and (2) those that do not reduce target RNA levels. Inhibition of RNA function by antisense oligodeoxynucleotides without affecting RNA stability may be due to the disruption of RNA-protein or RNA-RNA interactions that are essential for RNA translation into protein synthesis. Translation arrest without destabilizing mRNA has been demonstrated in vitro using compounds targeted to the translation initiation site (1 ,2 ). Binding of antisense oligodeoxynucleotides to the AUG start codon can inhibit translation initiation by inhibiting ribosome assembly (3 ).
        ad image
        提问
        扫一扫
        丁香实验小程序二维码
        实验小助手
        丁香实验公众号二维码
        扫码领资料
        反馈
        TOP
        打开小程序