A Reply to An Iconoclastic Approach to Pharmacodynamics in Model Systems: Their Relevance to Humans

As I lift up my pen to undertake this reply to the outstanding essay by David R. Blake, this being requested by himself and my co-editor Professor Paul Winyard, I feel myself becoming overcome by trepidation and fear. Frankly, I cannot write in the elegant style of David! Furthermore, I have always been convinced that David Blake is a direct descendant of William Blake (1757–1827), the artist, poet, and philosopher who was always wildly controversial, but outstanding in his perception of life and death.