Inflammatory Response of Tumor-Activated Hepatic Sinusoidal Endothelium as a Target for the Screening of Metastasis Chemopreventive Drugs
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The pathogenesis of cancer dissemination and metastasis involves a cascade of interdependent events (1 ). These are regulated by complex host-tumor cell interaction mechanisms, such as cancer cell adhesion to endothelium and extracellular matrix, cancer cell migration and invasion through stromal barriers, and cancer-induced immune cell disfunction and neo-angiogenesis. Proinflammatory cytokine blockade inhibits cancer metastasis development under experimental conditions (2 ,3 ), suggesting that proinflammatory mediators regulate host-tumor cell interactions contributing to arrest and implantation of disseminated cancer cells in target organs.
