• 我要登录|
  • 免费注册
    |
  • 我的丁香通
    • 企业机构:
    • 成为企业机构
    • 个人用户:
    • 个人中心
  • 移动端
    移动端
丁香通 logo丁香实验_LOGO
搜实验

    大家都在搜

      大家都在搜

        0 人通过求购买到了急需的产品
        免费发布求购
        发布求购
        点赞
        收藏
        wx-share
        分享

        Induction of Deoxyribonucleic Acid Damage by Alkylating Agents

        互联网

        781
        Alkylating agents are a series of potentially carcinogenic compounds that are able to introduce lesions into deoxyribonucleic acid (DNA; ref. 1 ). For their electrophilic nature, alkylating agents have an affinity for the nucleophilic centers of DNA and are monofunctional (have one reactive group) or bifunctional (have two reactive groups). Alkylating agents, such as methylmethanesulphonate and N -ethyl-N -nitrosourea, introduce methyl, ethyl, and complicated alkyl groups to the functional groups of nucleic acid bases, with ring nitrogens being generally more reactive than ring oxygens (2 4 ). The alkylation of oxygen in phosphodiester bonds results in phosphotriester formation (5 ) and bifunctional agents often react with two nucleophilic centers, producing inter- and intrastrand crosslinks (6 ).
        ad image
        提问
        扫一扫
        丁香实验小程序二维码
        实验小助手
        丁香实验公众号二维码
        扫码领资料
        反馈
        TOP
        打开小程序