Introduction: Cell-Based Assays for High-Throughput Screening
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Cell-based assays represent approximately half of all high-throughput screens (HTS) currently performed. Here we review the
            history and status of HTS, and summarize some of the challenges and benefits associated with the use of cell-based assays
            in HTS, drawing upon themes that will reemerge in subsequent chapters in this book. Approaches for successful experimental
            design and execution of cell-based HTS are introduced, including strategies for assay development, implementation of primary
            and secondary screens, and target identification. In doing so, we hope to provide a comprehensive review of the cell-based
            HTS process and an introduction to the methodologies and techniques described in this book.
         
      










