• 我要登录|
  • 免费注册
    |
  • 我的丁香通
    • 企业机构:
    • 成为企业机构
    • 个人用户:
    • 个人中心
  • 移动端
    移动端
丁香通 logo丁香实验_LOGO
搜实验

    大家都在搜

      大家都在搜

        0 人通过求购买到了急需的产品
        免费发布求购
        发布求购
        点赞
        收藏
        wx-share
        分享

        Assessment of Stress-Independent Binge-Like Eating Behavior in Mice

        互联网

        712
        In humans, binge eating is central to the harmful effects of bulimia and binge-eating disorder (BED). The development of preclinical mouse models of binge-like eating behavior has proved to be challenging, as minor stressors can significantly inhibit food intake in this species. Herein, we present two reinstatement models that can reliably induce binge-like eating behavior in mice. Both utilize a schedule of intermittent access to a palatable, high-energy-dense diet (HED). We describe the typical procedures for inducing binge-like eating behavior with daily 1-h or weekly 24-h free-choice access to the HED. No investigator-initiated caloric restriction or exogenous stressors are imposed to induce bingeing using either paradigm. We compare the results obtained with the two models and the unique features of both. The intermittent access to HED allows one to obtain reproducible binge-like eating behavior that can be maintained consistently for several weeks. Furthermore, these two hedonic feeding paradigms are highly reproducible across the common C57BL/6 and 129SvEv inbred mouse strains. Therefore, the models described herein may prove useful in the analysis of feeding behavior in genetically engineered mouse strains.
        ad image
        提问
        扫一扫
        丁香实验小程序二维码
        实验小助手
        丁香实验公众号二维码
        扫码领资料
        反馈
        TOP
        打开小程序