Patch-Cram Detection of Cyclic GMP in Intact Cells
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Information is transmitted throughout the nervous system by chemical and electrical signals. The cacophony of neuronal signals
            does not end at the cell surface, but continues deep into cells via diffusible intracellular messenger molecules. The list
            of molecules that serve as intracellular messengers continues to expand, but several stand out as very common examples, including
            Ca2+
, cyclic nucleotides (cAMP and cGMP), and inositol phospholipids and their metabolites (IP3
, diacylglycerol, etc.). Cellular responses to extracellular neurotransmitters are often mediated by one or more of these
            intracellular messengers, affording several functional advantages. Intracellular messengers allow spatial spread of signals
            within cells, contribute to amplification of signals, and allow responses to persist even after the neurotransmitter is gone
            from outside the cell. Intracellular messenger systems are also advantageous because they participate in a great degree of
            “crosstalk,” increasing the repertoire of responses to a given external stimulus and allowing for biochemical computation
            at the level of an individual cell.
         
      










