Incorporation of Stable Pseudopeptide Bonds: Methylene Amino, Thioether, and Hydroxyethylene Derivatives
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The introduction of pseudopeptide bonds (amide bond surrogates) into the peptide backbone during synthesis is now a common
technique in peptide chemistry (1
). These pseudo-peptide bonds are introduced in order to satisfy criteria such as stability to enzymatic degradation, transition
state analogs/enzyme inhibition, alteration in peptide backbone conformation (with corresponding changes in flexibility and
hydrogen-bonding character), increased receptor specificity, increased potency, and biological responses (2
).
![N-[2-[4-[[6-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethyl]-2-azaspiro[3.3]heptan-2-yl]methyl]cyclohexyl]-5-(2-hydroxypropan-2-yl)-1,3-benzothiazol-6-yl]-6-(trifluoromethyl)pyridine-2-carboxamide，Moligand™，阿拉丁](https://img1.dxycdn.com/p/s14/2024/0619/785/8670042233826733081.jpg!wh200)
