• 我要登录|
  • 免费注册
    |
  • 我的丁香通
    • 企业机构:
    • 成为企业机构
    • 个人用户:
    • 个人中心
  • 移动端
    移动端
丁香通 logo丁香实验_LOGO
搜实验

    大家都在搜

      大家都在搜

        0 人通过求购买到了急需的产品
        免费发布求购
        发布求购
        点赞
        收藏
        wx-share
        分享

        Treatment of Liver Tumors in Rabbit

        互联网

        582
        Electrochemotherapy has been proven to be efficient for the treatment of subcutaneous tumors of different histological types in mice, rats and cats (1 3 ). Electrochemotherapy is essentially a local treatment. Indeed, it is based on the potentiation of the cytotoxicity of a low-permeant drug, typically bleomycin, by tumor cell permeabilization using brief and intense electric pulses. In the tissues exposed to such electric pulses, the so-called cell electropermeabilization is obtained only in the volume crossed by an electric field of intensity higher than a threshold value (4 ). The existence of this threshold for tissue permeabilization implies that the potentiation of the cytotoxic drug by the applied electric pulses is limited to the space roughly comprised between the electrodes. In the case of rather small and prominent cutaneous or subcutaneous tumors, it is easy to place two external electrodes on each side of the tumor nodule to be treated and to transcutaneously deliver the permeabilizing electric pulses. For thick and for deep subcutaneous tumors as well as for tumors located in internal organs, this electrode configuration is not appropriate because the electric pulses have to be delivered directly to the tumor tissues. Externally placed electrodes simply do not supply electric fields that extend deep enough for these situations. Intratumoral electric pulse delivery can, however, be achieved using needle-electrodes that are inserted into the tumor volume. We have designed an applicator constituted by multiple parallel and equidistant needles in order to avoid the delivery of very high-voltage electric pulses. A specifically manufactured generator ensures the multiplexed supplying of the electric current to each pair of closest needle electrodes. Thus, the entire tumor volume is divided in small units which are separately permeabilized by the different pairs of closest electrodes.
        ad image
        提问
        扫一扫
        丁香实验小程序二维码
        实验小助手
        丁香实验公众号二维码
        扫码领资料
        反馈
        TOP
        打开小程序