Herpes Simplex Virus Life Cycle and the Design of Viral Vectors
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Herpes simplex viruses types 1 and 2 (HSV-1 and HSV-2) are doublestranded DNA viruses with a genome size of 152 kbp. The genome consists of two unique regions, UL (long) and Us (short), flanked by repeated sequences (Fig. 1 ; for review, see ref. 1 ). The two viruses are closely related, and both infect humans, producing mucocutaneous sores that are predominantly facial in the case of HSV-1 and genital in the case of HSV-2.
