Methods in Cyclic Nucleotide Research
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Cyclic nucleotides were discovered about 30 years ago, becoming the prototype intracellular messengers (Robison et al., 1971 ). Intracellular messenger signaling systems may be split into the following divisions:
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Generation of the signal;
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| 2. |
Removal of the signal (generally this occurs by metabolism, although Ca2+ is an obvious exception);
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| 3. |
Direct mediators of the signal; and
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| 4. |
Ultimate effects of the signal.
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