Development of an On-Site Measurement System for Salivary Stress-Related Substances Based on Microchip CE

Secretory immunoglobulin A (sIgA) in saliva has been suggested to be a potential marker of chronic, long-term stress due to suppression of the immune system. A rapid point-of-care testing platform for stress measurement based on immunoassay and capillary electrophoresis (CE) separation was �developed using a poly(methyl methacrylate) (PMMA) chip and a laboratory-built microchip CE system. A method for the quantitative determination of sIgA in human saliva is introduced.