CD8分子
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CD8 分子
CD8
常用单克隆抗体或代号：α链：T8，Leu2a，UCHT4，
β链：T8／2T8，5H7
主要表达细胞：Tsub(α/β，Thysub，IEL，NKsub(α/α)[T]
分子质量(kDa)和结构：gp(36／32)，α/α或α/β二聚体(1sSF)
功 能：与MHCI类分子结合，信号转号
CD8
Aka OKT8, T cell suppressor/cytotoxic cells
On chromosome #2
MHC class I restricted receptor; binds to nonpolymorphic region of class I molecules; may increase avidity of cell-cell interactions
Associated with lymphoepithelioma-like carcinoma of lung (AJSP 2002;26:715)
Positive staining (normal): T cells (25-35% of mature peripheral T cells, most cytotoxic T cells, CD4/CD8+ thymocytes); NK cells (30%-which are also CD3 negative); cortical thymocytes (70-80%), epidermotrophic lymphocytes in mycosis fungoides (AJSP 2002;26:450)
Micro images: lymphoepithelioma-like carcinoma of cervix-figure 3, acute demyelinating disease
Micro images (Mod Path subscribers): nodal cytotoxic T cell lymphoma
Reference: Mod Path 2002;15:1131
