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        【资源】Nature Reviews Immunology 2011年11月刊

        丁香园论坛

        872
        Table of contents

        November 2011 Vol 11 No 11




        【资源】Nature Reviews Immunology 2011年11月刊

        About the cover

        In this issue

        p713 | doi:10.1038/nri3102

        Editorial: Nobel Prize to immunology

        p714 | doi:10.1038/nri3103

        Top of page

        Research Highlights

        Immunotherapy: Stopping monocytes in their tracks | PDF (416 KB)


        p715 | doi:10.1038/nri3096

        Therapeutic targeting of inflammatory monocyte migration attenuates disease severity.

        T cell memory: The stem of T cell memory | PDF (283 KB)

        p716 | doi:10.1038/nri3098

        Identification of human T memory stem cells with increased therapeutic potential.

        B cell signalling: Right place, right time | PDF (150 KB)

        p716 | doi:10.1038/nri3100

        BCR endocytosis compartmentalizes kinase phosphorylation and downstream signalling.

        T cell memory: Exhausted T cells miss out on methylation | PDF (190 KB)

        p718 | doi:10.1038/nri3093

        The inhibitory signal to T cells through PD1 is sustained during chronic viral infection by epigenetic mechanisms.

        Tumour immunology: IFNs boost cancer killers | PDF (235 KB)

        p718 | doi:10.1038/nri3094

        Type I IFN targets CD8α+ DCs for the initiation of antitumour immunity.

        Immune tolerance: Suicide is painless | PDF (437 KB)

        p719 | doi:10.1038/nri3092

        Self-reactive T cells invade and are degraded in hepatocytes, preventing autoimmune disease.

        T cells: Lymphoid stroma says NO to activated T cells | PDF (211 KB)

        p720 | doi:10.1038/nri3090

        Activated T cells induce the production of immunosuppressive nitric oxide by stromal cells.

        Neuroimmunology: Nervous ChAT | PDF (208 KB)

        p720 | doi:10.1038/nri3091

        Acetylcholine-producing T cells convey neural signals to dampen inflammation.

        Mucosal immunology: Colonic creatures are TReg teachers | PDF (317 KB)

        p721 | doi:10.1038/nri3099

        Most regulatory T cells in the colon are specific for commensal bacteria.

        In brief

        Macrophages: Arteriogenic macrophages protect against ischaemia | PDF (124 KB)


        p716 | doi:10.1038/nri3097

        Monocytes: How a high-fat diet results in monocytosis | PDF (124 KB)

        p716 | doi:10.1038/nri3104

        Technique: Recapitulating human TB in vitro | PDF (124 KB)

        p716 | doi:10.1038/nri3105

        T cells: Natural TH17 cell development in the thymus | PDF (113 KB)

        p717 | doi:10.1038/nri3101

        Cytokines: IL-1 family member dampens intestinal inflammation | PDF (113 KB)

        p717 | doi:10.1038/nri3106

        Innate immunity: The function of innate lymphoid cells in the lung | PDF (113 KB)

        p717 | doi:10.1038/nri3107

        Top of page

        Focus on: Monocytes and macrophages

        Reviews

        Protective and pathogenic functions of macrophage subsets


        Peter J. Murray & Thomas A. Wynn

        p723 | doi:10.1038/nri3073

        Macrophages exhibit remarkable plasticity and adopt pro- or anti-inflammatory phenotypes in response to environmental signals. This Review article by Murray and Wynn discusses the different macrophage subsets and their contribution to tissue homeostasis and disease pathogenesis.



        Macrophage-mediated inflammation in metabolic disease

        Ajay Chawla, Khoa D. Nguyen & Y. P. Sharon Goh

        p738 | doi:10.1038/nri3071

        Inflammation in adipose tissue is known to mediate insulin resistance in obesity, and macrophages are thought to have a central role in mediating this inflammatory response. But adipose tissue macrophages are not all bad: alternative activation of these cells promotes insulin sensitivity.



        Transcriptional regulation of macrophage polarization: enabling diversity with identity

        Toby Lawrence & Gioacchino Natoli

        p750 | doi:10.1038/nri3088

        This Review describes the key transcription factors that enable the polarization of macrophages in response to the microenvironment in the context of a regulatory landscape that determines macrophage identity.



        Monocyte recruitment during infection and inflammation

        Chao Shi & Eric G. Pamer

        p762 | doi:10.1038/nri3070

        Monocytes serve as precursors for various tissue macrophage and dendritic cell populations and contribute to both protective and pathological immune responses. Here, the authors describe the mechanisms that are involved in mobilizing monocytes to distinct tissue sites, both during steady-state conditions and in response to infection.



        Microglial cell origin and phenotypes in health and disease

        Kaoru Saijo & Christopher K. Glass

        p775 | doi:10.1038/nri3086

        Microglia are brain-resident macrophages with a distinct origin. This Review discusses the development and function of these cells, and describes the association between the different microglial cell phenotypes and disease.



        Studying the mononuclear phagocyte system in the molecular age

        Andrew Chow, Brian D. Brown & Miriam Merad

        p788 | doi:10.1038/nri3087

        Immunologists are making good progress in unravelling the intricacies of the mononuclear phagocyte system, and this is largely due to recent technological advances. This article describes the current tools that exist for studying the origins and functions of mononuclear phagocytes and discusses the future technologies that will enable further progress in the field.

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