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        Liposomes Containing Ligands: Binding Specificity to Selectins

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        Carbohydrate-binding proteins have attracted much attention as they are often considered to be mediators of specific cell adhesion (1 5 ). It has been suggested that the neutrophils utilize at least three types of adhesion molecules for homing to the sites of inflammation. These are members of the lectinepidermal growth factor-complement related-cell adhesion molecule (LECCAM), integrin, and Ig gene superfamilies (6 ,7 ). The LEC-CAM family of adhesion molecules has recently been recognized to play a central role in mediating leukocyte-endothelial cell interaction. The term selectin is now commonly used to represent three members of this LEC-CAM family: L-, E-, and P-selectin. The lectin character of these cell adhesion molecules (CAMs) makes the selectin family unique among all the known CAM families (8 10 ).
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