Generation and Application of Phospho-specific Antibodies for p53 and pRB
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The functions of many proteins are likely to be regulated by phosphorylation. Thus, antibodies that can recognize specifically phosphorylated sites on proteins have a wide variety of uses for studying the function and regulation of phosphoproteins. We have improved methods for generation of phosphorylation site-specific antibodies and have successfully obtained antibodies for the analysis of most of the phosphorylation sites on p53 and RB proteins.
