Lipopolysaccharide Chemotyping
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Lipopolysaccharide (LPS), traditionally termed somatic antigen or O-antigen, forms an integral part of the outer membrane of Gram-negative bacteria. In general, LPS consists of essentially three parts:
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A hydrophobic portion, lipid A, which is composed of long-chain fatty acids and which anchors LPS molecules into the outer membrane;
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| 2. |
The core region; and
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| 3. |
The long-chain LPS, which is comprised of polymers of oligosaccharide units and contains the epitopes involved in LPS serotyping reactions.
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