Wnt Signaling Mediates Diverse Developmental Processes in Zebrafish

A combination of forward and reverse genetic approaches in zebrafish has revealed novel roles for canonical Wnt and Wnt/PCP signaling during vertebrate development. Forward genetics in zebrafish provides an exceptionally powerful tool to assign roles in vertebrate developmental processes to novel genes, as well as elucidating novel roles played by known genes. This has indeed turned out to be the case for components of the canonical Wnt signaling pathway. Non-canonical Wnt signaling in the zebrafish is also currently a topic of great interest, due to the identified roles of this pathway in processes requiring the integration of cell polarity and cell movement, such as the directed migration movements that drive the narrowing and lengthening (convergence and extension) of the embryo during early development.