• 我要登录|
  • 免费注册
    |
  • 我的丁香通
    • 企业机构:
    • 成为企业机构
    • 个人用户:
    • 个人中心
  • 移动端
    移动端
丁香通 logo丁香实验_LOGO
搜实验

    大家都在搜

      大家都在搜

        0 人通过求购买到了急需的产品
        免费发布求购
        发布求购
        点赞
        收藏
        wx-share
        分享

        Methods for Detecting Lytic Granules in Natural Killer Cells

        互联网

        868
        Natural killer (NK) cells are able to identify and destroy target cells with absent or altered major histocomaptibility complex (MHC) class I, thereby mediating “natural cytotoxicity.” They also have the capacity to kill antibodycoated target cells by antibody-dependent cellular cytotoxicity (ADCC). The proteins that mediate these killing processes are stored in specialised secretory granules in the NK cells. When the NK cell recognizes its target these granules polarize toward the point of membrane contact and secrete their contents into the space between the cells. The major components of these granules are known (reviewed in ref. 1 ) and one of these proteins, perforin, inserts into the target cell membrane polymerizing to form a pore through which other proteins (granzymes) can pass and initiate cell death through the apoptotic pathway. Perforin alone can lyse the target cells by the formation of membrane pores although this process is relatively slow and it is likely that the granzymes are critical in effecting rapid cell death in vivo.
        ad image
        提问
        扫一扫
        丁香实验小程序二维码
        实验小助手
        丁香实验公众号二维码
        扫码领资料
        反馈
        TOP
        打开小程序