Reconstitution of Functional Integrin into Phopsholipid Vesicles and Planar Lipid Bilayers
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Integrins are heterodimeric cell-surface receptors involved in a variety of functions such as binding to the ECM, regulation of the cellular organization, cell migration, proliferation, differentiation, and gene expression (1 ,2 ). Integrins in their native environment can diffuse in the plane of the membrane, and this mobility is required for processes like the assembly of integrins to focal contacts or cell migration (3 ,4 ).
