Model-Free Linkage Analysis of a Quantitative Trait

Model-free methods of linkage analysis for quantitative traits are a class of easily implemented, computationally efficient, and statistically robust approaches to searching for linkage to a quantitative trait. By “model-free” we refer to methods of linkage analysis that do not fully specify a genetic model (i.e., the causal allele frequency and penetrance functions). In this chapter, we briefly survey the methods that are available, and then we discuss the necessary steps to implement an analysis using the programs GENIBD, SIBPAL, and RELPAL in the Statistical Analysis for Genetic Epidemiology (S.A.G.E.) software suite.