Separation of Racemic 1-(9-Anthryl)-2,2,2-trifluoroethanol by Sub-/Supercritical Fluid Chromatography

Supercritical fluid chromatography is an environmentally benign separation technology due to the use of carbon dioxide modified with organic solvents as the mobile phase. It has found widespread use in the separation of chiral compounds based on the relative ease of method development and high likelihood of success for obtaining acceptable chromatographic performance while providing short analysis time. In this chapter, we describe the separation of racemic 1-(9-Anthryl)-2,2,2-trifluoroethanol on a Phenomenex Lux Cellulose-1 column using methanol as the modifier and detection by UV at 230 nm.