• 我要登录|
  • 免费注册
    |
  • 我的丁香通
    • 企业机构:
    • 成为企业机构
    • 个人用户:
    • 个人中心
  • 移动端
    移动端
丁香通 logo丁香实验_LOGO
搜实验

    大家都在搜

      大家都在搜

        0 人通过求购买到了急需的产品
        免费发布求购
        发布求购
        点赞
        收藏
        wx-share
        分享

        Translational Regulation of Synaptic Plasticity

        互联网

        760
        Synaptic plasticity defines the process by which synapses, the connections between neurons, can be modified in response to activity. Plasticity can be either positive or negative, with strengthening and weakening of synapses occurring with distinct patterns of activity (neuronal “experience”). These plastic changes can be transient (lasting seconds to minutes) or can persist for days to months. Long-lasting forms of synaptic plasticity are supported by the de novo synthesis of macromolecules. This process can be broadly divided into transcription of DNA into new messenger RNAs and translation of mRNAs into new proteins. A very useful experimental platform for studying these processes is the rodent ex vivo hippocampal slice preparation. Hippocampal slices can be utilized for pharmacological, biochemical, and electrophysiological experiments aimed at studying mechanisms upstream and downstream of the macromolecular synthesis underlying persistent synaptic plasticity.
        ad image
        提问
        扫一扫
        丁香实验小程序二维码
        实验小助手
        丁香实验公众号二维码
        扫码领资料
        反馈
        TOP
        打开小程序