CD64分子
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CD64 分子
CD64
常用单克隆抗体或代号： MAb32.2,MAb22;(Fcg RI)
主要表达细胞： M [M]
分子质量(kDa)和结构： gp75(IgSF)
功 能： 吞噬、ADCC,Mac活化
CD64
Aka Fc gamma RI
High affinity receptor binds to Fc region of IgG
Important in phagocytosis via receptor-mediated endocytosis of IgG-antigen complexes
Mediates antigen capture for presentation to T cells, antibody-dependent cellular cytotoxicity, release of cytokines and reactive oxygen intermediates
Positive staining (normal): Macrophages/monocytes, activated granulocytes, dendritic cells, early myeloid cells
Positive staining (disease): AML M0-M2 (variable); M3 (usually); M4, M5
Negative staining: AML M7
