• 我要登录|
  • 免费注册
    |
  • 我的丁香通
    • 企业机构:
    • 成为企业机构
    • 个人用户:
    • 个人中心
  • 移动端
    移动端
丁香通 logo丁香实验_LOGO
搜实验

    大家都在搜

      大家都在搜

        0 人通过求购买到了急需的产品
        免费发布求购
        发布求购
        点赞
        收藏
        wx-share
        分享

        Arf6 and its Role in Cytoskeletal Modulation

        互联网

        635
        The Arf family of GTP-binding proteins is highly conserved and widely expressed in eukaryotic cells. Arfs can be divided into three classes based on amino-acid sequence. Class I Arfs include mammalian Arfs 1-3, Class II includes Arfs 4, and 5, and Class III Arfs have only one member-Arf6 (1 ). All Arf proteins have been shown to share a number of biochemical properties in vitro including: serving as cofactors in the ADP-ribosylation of Gs-alpha subunits induced by cholera toxin, activating phospholipase D (PLD), and activating phosphatidylinositol 4-phosphate 5-kinase (2 ). However, since each Arf is broadly expressed, they must serve specific functions in cells. Our goal has been to define these functions in cells. Of these proteins, Arf1 is the most widely studied in cells and in biochemical assays. It is involved in the regulation of membrane traffic between the endoplasmic reticulum (ER) and Golgi complex and in the maintenance of the organization of the Golgi complex (3 ). Arf1 serves this dual function through the modification of Golgi-membrane lipid composition and the assembly of cytosolic coat-protein complexes onto Golgi membranes.
        ad image
        提问
        扫一扫
        丁香实验小程序二维码
        实验小助手
        丁香实验公众号二维码
        扫码领资料
        反馈
        TOP
        打开小程序