NeuropeptideYY5 Receptor Expression
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Neuropeptide Y (NPY) is one of the most abundant neuropeptides in the mammalian nervous system and is an important mediator
of numerous physiological effects (1
). NPY elicits its manifold biological effects by interacting with at least six different G-protein-coupled receptors known
as Y1, Y2, Y3, Y4, Y5, and y6 (2
). The NPY Y1 and Y5 receptors have recently been the subject of intense basic research and drug development efforts because
these two receptors appear to mediate the effects of NPY on food intake and the regulation of body weight. Unfortunately,
the study of the NPY Y1 and Y5 receptors has been hampered by difficulties in expressing these two receptors in cultured cells.
