Measurement of Efflux Rates from Brain to Blood
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The blood-brain barrier (BBB) regulates the exchange of substances between the fluids of the central nervous system (CNS)
and the blood (1
). As such, the BBB is actively involved in providing nutrition and maintaining the homeostatic environment for the brain
and spinal cord. Recently, the BBB has been postulated to be important in communication between the nervous system and the
peripheral tissues through its ability to control the exchange of regulatory substances (2
,3
). Furthermore, the BBB is increasingly being found to play important and active roles in disease states (4
–9
).
