• 我要登录|
  • 免费注册
    |
  • 我的丁香通
    • 企业机构:
    • 成为企业机构
    • 个人用户:
    • 个人中心
  • 移动端
    移动端
丁香通 logo丁香实验_LOGO
搜实验

    大家都在搜

      大家都在搜

        0 人通过求购买到了急需的产品
        免费发布求购
        发布求购
        点赞
        收藏
        wx-share
        分享

        Ras and Rac as Activators of Reactive Oxygen Species (ROS)

        互联网

        881
        The investigation into the relationship between reactive oxygen species (ROS) and the signaling pathways of the Ras family of small GTPases has experienced a recent surge in interest. Known to cause DNA damage, and implicated in disease processes as wide-ranging as atherosclerosis and kidney disease, ROS have appeared in unlikely capacities within the Ras signaling pathway. Eschewing their evil ways, ROS have been shown to be essential for mitogenesis in Ras-transformed cells, and have been identified as mediators of a Rac-dependent anti-apoptotic signal in cells microinjected with activated Ras (1 ,2 ). The beneficence of ROS on Ras-transformed cells carries with it the macroscopic potential for selection and growth promotion of cancerous cells. Several investigations have suggested such a role for ROS, specifically superoxide (O2 s ), in a Ras-independent manner. Populations of SV40-transformed cells have been observed to undergo phenotypic reversion when transfected with Mn SOD,an enzyme that converts superoxide to hydrogen peroxide. Moreover, several investigations have demonstrated decreased levels of MnSOD in populations of cancerous cells (3 ,4 ). Together, these studies suggest a requirement for superoxide in the maintenance of the transformed state.
        ad image
        提问
        扫一扫
        丁香实验小程序二维码
        实验小助手
        丁香实验公众号二维码
        扫码领资料
        反馈
        TOP
        打开小程序