Targeted Cleavage of RNA Using External Guide Sequences and Eukaryotic RNase P
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Most human diseases are a result of the dysfunction of cellular genes or a result of the invasion of cells by foreign genetic materials. Blocking disease-causing genes from making the proteins they specify is a strategy for combating disease processes. Antisense and ribozyme are two widely known approaches toward accomplishing this objective. This chapter describes a novel approach for inactivation of any particular gene in cells using endogenous ribonuclease P.
