Localization of Epithelial Sodium Channels by Atomic Force Microscopy
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Epithelial sodium channels (ENaC) mediate Na reabsorption across a variety of sodium reabsorbing epithelia, such as the kidney, distal colon, and airway. Normal function of these channels is critical for processes as diverse as blood volume control and airway fluid homeostasis. The molecular cloning of ENaC from a variety of epithelial cells has revealed that they are composed of three homologous subunits, such as α, β, and γ (1 ).
