Oligonucleotide Analogs Containing Dephospho-Internucleoside Linkages

Nonionic oligonucleotide analogs have attracted much interest in recent years as potential candidates for oligonucleotide-based therapeutics. Compared to their natural parent molecules, they are expected to have the advantage of:

1.	Being stable against degrading nucleases,
2.	Showing enhanced cellular uptake, and
3.	Having the ability to form more stable complexes with complementary sequences owing to reduced charge repulsion.