• 我要登录|
  • 免费注册
    |
  • 我的丁香通
    • 企业机构:
    • 成为企业机构
    • 个人用户:
    • 个人中心
  • 移动端
    移动端
丁香通 logo丁香实验_LOGO
搜实验

    大家都在搜

      大家都在搜

        0 人通过求购买到了急需的产品
        免费发布求购
        发布求购
        点赞
        收藏
        wx-share
        分享

        Analysis of Nitrite and Nitrate in the Study of Inflammation

        互联网

        704
        An acute inflammatory response is mounted in response to a stimulus such as tissue damage or the presence of an invading pathogen (1 ). If this stimulus cannot be removed, then chronic inflammation will develop as classically shown in rheumatoid arthritis (RA). Along with the array of cytokines and chemokines released during inflammation infiltrating macrophages and neutrophils release nitric oxide (NO ), which is involved in killing the offending organism (2 ,3 ). Additionally, NO is known to mediate the inflammatory response by inhibiting or inducing inflammation via a variety of different pathways (4 8 ). For example, NO has been shown to activate and inhibit the transcription factor, nuclear factor-kappa B (NF-κB) (9). When NO activates NF-κB it induces the generation of proinflammatory cytokines such as tumor necrosis factor alpha (TNFα), which are thought to drive the chronic inflammatory response (10 ). However, NO can also cause the inhibition of NF-κB by upregulating the production of its inhibitor IκB (11 ,12 ). In a similar way, NO has been shown to inhibit neutrophil adhesion, preventing white blood cells (WBC) from infiltrating the site of inflammation (13 ). NO also increases the vascular permeability of the vessel wall so that WBCs can reach the affected tissue (14 ). The level of NO produced is thought to determine whether NO acts as a proinflammatory or antiinflammatory mediator. In many cases, the formation of peroxynitrite, from NO and superoxide, is thought to be responsible for some of the proinflammatory actions of NO (15 ).
        ad image
        提问
        扫一扫
        丁香实验小程序二维码
        实验小助手
        丁香实验公众号二维码
        扫码领资料
        反馈
        TOP
        打开小程序