A Novel Test Battery to Assess Drug-Induced Changes in Zebrafish Social Behavior
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The zebrafish (Danio rerio
) has been at the forefront of neurobiological research and is steadily gaining favor as a model organism for behavioral applications.
The ease of handling, high yield of progeny, and efficient mode of drug delivery make this species a particularly useful model
for behavioral screening. Various drug classes have a range of physiological effects that can impact motor output and social
behavior. Using a behavioral paradigm in drug screening can be a useful tool, from determining dose ranges and toxicity to
drug-induced behavioral changes. Here we propose a novel behavioral paradigm to assess the group dynamics of zebrafish. This
protocol describes methods for simple, fast, and accurate assessment of drug-induced effects on motor and social behavior.
