Introduction to Comparing Large Sequence Sets
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Abstract
Comparisons of whole genomes can yield important insights into the evolution of genome structure, such as the role of inversions in bacterial evolution and the identification of large?scale duplications in the human genome. This unit briefly compares two tools for aligning whole genome sequences: MUMmer and PipMaker. These tools differ in both the underlying algorithms used, and in the interface they present to the user.
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Literature Cited
| Literature Cited | |
| Eisen, J.A., Heidelberg, J.F., White, O., and Salzberg, S.L. 2000. Evidence for symmetric chromosomal inversions around the replication origin in bacteria. Genome Biol. 1:1101‐1109. | |
| Venter, J.G., Adams, M.D., Myers, E.W., Li, P.W., Mural, R.J., Sutton, G.G., Smith, H.O., Yandell, M., Evans, C.A., Holt, R.A. et al. 2001. The sequence of the human genome. Science 291:1304‐1351. |
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