丁香实验_LOGO
登录
提问
我要登录
|免费注册
点赞
收藏
wx-share
分享

In Vitro and In Vivo Models for Evaluation of GDEPT: Quantifying Bystander Killing in Cell Cultures and Tumors

互联网

338
The vectors currently available for gene therapy of cancer rarely achieve expression of therapeutic genes in more than a small fraction of the cells in solid tumors. This makes therapeutic success critically dependent on secondary events, known as bystander effects, by which transgene expression leads to the death of nontransduced tumor cells. An efficient bystander effect has the potential to compensate for spatially nonuniform expression of therapeutic genes, and its optimization is therefore an important goal in gene therapy of cancer. Here, we describe protocols for quantifying bystander effects using in vitro and in vivo experimental models.
ad image
提问
扫一扫
丁香实验小程序二维码
实验小助手
丁香实验公众号二维码
扫码领资料
反馈
TOP
打开小程序