Peptoids and PeptidePeptoid Hybrid Biopolymers as Peptidomimetics
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Peptoids (oligomers of N
-substituted glycine residues) and peptide–peptoid hybrid polymers (peptomers) are interesting classes of compounds mimicking
structure and function of biologically active peptides. The oligomeric peptidomimetics such as peptoids are particularly important
compounds since they provide access to an enormous molecular diversity, by variation of the building blocks. The modular structure
of peptoids, ease of synthesis, and high compatibility with existing peptide chemistry synthetic protocols, make peptoids
and peptoid-containing peptidomimetics ideal tools for structure–activity and drug discovery related studies.
