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This work reviews present technologies and developing trends in Point-of-Care (POC) microfluidic diagnostics platforms. First, various fluidics technologies such as pressure-driven flows, capillary flows, electromagnetically driven flows, centrifugal fluidics, ac ...

Various solid freeform fabrication technologies have been introduced for constructing three-dimensional (3-D) freeform structures. Of these, microstereolithography (MSTL) technology performs the best in 3-D space because it not only has high resolution, but also fast fabric ...

A paradigm shift is taking place in orthopaedic and reconstructive surgery. This transition from using medical devices and tissue grafts towards the utilization of a tissue engineering approach combines biodegradable scaffolds with cells and/or biological molecules in order to r ...

Minimization schema in nature affects the material arrangements of most objects, independent of scale. The field of cellular solids has focused on the generalization of these natural architectures (bone, wood, coral, cork, honeycombs) for material improvement and elucidation into ...

Two-photon polymerization (2PP) technique is a novel CAD/CAM-based technology allowing the fabrication of any computer-designed 3D structure from a photosensitive polymeric material with a lateral resolution down to 100 nm. The fabrication of highly reproducible scaffold str ...

Laser sintering (LS) utilises a laser to sinter powder particles. A volumetric model is sliced and processed cross section by cross section to create a physical part. In theory, all powdered materials are suitable for sintering; however, only few have been tested successfully. For tissue engi ...

Our ability to create precise, predesigned, spatially patterned biochemical and physical microenvironments inside polymer scaffolds could provide a powerful tool in studying progenitor cell behavior and differentiation under biomimetic, three-dimensional (3D) cult ...

Designing and manufacturing of vascular prosthesis for arterial bypass grafts is a very complex problem. The process involves the selection of suitable geometry, materials of appropriate characteristics, and manufacturing technique capable of constructing prosthesis in a c ...

Computer-aided tissue engineering enables the fabrication of multifunctional scaffolds that meet the structural, mechanical, and nutritional requirements based on optimized models. In this chapter, three-dimensional printing technology is described, and several lim ...

The design of optimal bioreactor systems for tissue engineering applications requires a sophisticated understanding of the complexities of the bioreactor environment and the role that it plays in the formation of engineered tissues. To this end, a tissue growth model is developed to cha ...

Rapid prototyping technologies were recently introduced in the medical field, being particularly viable to produce porous scaffolds for tissue engineering. These scaffolds should be biocompatible, biodegradable, with appropriate porosity, pore structure, and pore distr ...

Rapid prototyping technologies were recently introduced in the medical field, being particularly viable to produce porous scaffolds for tissue engineering. These scaffolds should be biocompatible, biodegradable, with appropriate porosity, pore structure, and pore distr ...

Numerical modeling becomes a very useful tool for design and preclinical evaluation of scaffold for tissue engineering. This chapter illustrates, how finite element analysis and genetic algorithm maybe applied to predict the mechanical performance of novel scaffolds, with a hone ...

The Taguchi method together with Minitab software was used to optimize the melt spun PLLA multifilament fiber finesse. The aim was to minimize the number of spinning experiments to find optimal processing conditions and to maximize the quality of the fibers (thickness, strength, and smoot ...

Tissue engineering is the application of interdisciplinary knowledge in the building and repairing of tissues. Generally, an engineered tissue is a combination of living cells and a support structure called a scaffold. The scaffold provides support for bone-producing cells and can be u ...

Computer-aided technologies like computer-aided design (CAD), computer-aided manufacturing (CAM), and a lot of other features like finite element method (FEM) have been recently employed for use in medical ways like in extracorporeal bone tissue engineering strategies. Aim of this ...

To create composite synthetic scaffolds with the same degree of complexity and multilevel organization as biological tissue, we need to integrate multilevel biomaterial processing in rapid prototyping systems. The scaffolds then encompass the entire range of properties, which ...

The goal of this area of research is to manipulate the pore space of scaffolds through the application of an intelligent design concept on dissolvable microparticles. To accomplish this goal, we developed an efficient and repeatable process for fabrication of microparticles from multi ...

Computer-aided system for tissue scaffolds (CASTS) is an in-house parametric library of polyhedral units that can be assembled into customized tissue scaffolds. Thirteen polyhedral configurations are available to select, depending on the biological and mechanical requirem ...

This chapter briefly describes the concepts underlying medical imaging reconstruction and the requirements for its integration with subsequent applications as BioCAD, rapid prototyping (RP), and rapid manufacturing (RM) of implants, scaffolds, or organs. As an introduction to ...