数据库

Abstract Table of Contents Figures Literature Cited Abstract The first part of this unit compares general and locus?specific mutation databases. The second section deals with submitting data. The third part provides guidance for accessing

Abstract Table of Contents Figures Literature Cited Abstract In recent years, several proteomic methodologies have been developed that now make it possible to identify, characterize, and comparatively quantify the relative level of express

Abstract Table of Contents Figures Literature Cited Abstract Expression profiling of biological samples using microarray technologies has proven to be a powerful tool for molecular classification and biomarker identification. Visualization

Abstract Table of Contents Figures Literature Cited Abstract The CorePromoter program is very useful for identification of transcriptional start sites (TSS) and core promoter regions when 5??upstream genomic DNA sequences of human genes ar

Abstract Table of Contents Figures Literature Cited Abstract The Gibbs Motif Sampler (Gibbs) is a software package for discovering conserved elements in biopolymer sequences. This unit describes the basic operation of the Web?based interfa

Abstract Table of Contents Materials Figures Literature Cited Abstract Prediction of molecular function of proteins has become an important task in the genomics era. A wide variety of sequence analysis to

Abstract Table of Contents Figures Literature Cited Abstract The most popular current method of determining protein valence entails the calculation of net charge from amino acid sequence/composition. However, the inaccuracy of that approac

Abstract Table of Contents Materials Figures Literature Cited Abstract This unit describes methods that can accurately determine the genotypes and phenotypes of human complement components C4A and C4B. Sp

Abstract Table of Contents Figures Literature Cited Abstract This unit describes how to use the Parallel Contig Assembly Program (PCAP) to assemble the data produced by a whole?genome shotgun sequencing project. We present a basic protocol

Abstract Table of Contents Figures Literature Cited Abstract With the explosion in sequence data, accurate prediction of protein function has become a vital task in prioritizing experimental investigation. While computationally efficient m

Abstract Table of Contents Figures Literature Cited Abstract This unit describes the use of RasMol, a popular interactive molecular graphics program, for the display of biomolecular structures. The unit begins with a general guide to obtai

Abstract Table of Contents Figures Literature Cited Abstract High?throughput protein?protein interaction data are becoming a foundation for new biological discoveries. A major challenge is to manage, analyze, and model these data. In this

Abstract Table of Contents Figures Literature Cited Abstract Chado is a relational database schema that can be used to manage a wide variety of biological information, including genome annotation, genetic, phenotypic, and expression data.

Abstract Table of Contents Figures Literature Cited Abstract An annotation is any feature that can be tied to genomic sequence, such as an exon, transcript, promoter, or transposable element. As biological knowledge increases, annotations

Abstract Table of Contents Figures Literature Cited Abstract The Biomolecular Interaction Network Database (BIND) comprises data from peer?reviewed literature and direct submissions. BIND's data model was the first of its kind to be peer?r

Abstract Table of Contents Materials Figures Literature Cited Abstract Bioluminescence resonance energy transfer (BRET) allows monitoring of protein?protein interactions in real time in living cells. One

Abstract Table of Contents Figures Literature Cited Abstract The huge potential repertoire of 1012 immunoglobulins and 1012 T cell receptors per individual results from complex mechanisms of combinatorial diversity between the variable (V),

Abstract Table of Contents Figures Literature Cited Abstract Pharmabase is designed to form a bridge between the molecular dimension of cell transport processes and the functional manipulation of the protein players. It has as its emphasis

Abstract Table of Contents Figures Literature Cited Abstract RNAstructure is a user?friendly program for the prediction and analysis of RNA secondary structure under Microsoft Windows. This unit provides protocols for RNA secondary structu

Abstract Table of Contents Figures Literature Cited Abstract For most systems in biology, a large body of literature exists that describes the complexity of the system based on experimental results. Manual review of this literature to extr