生物信息学技术

Abstract Table of Contents Figures Literature Cited Abstract This unit assumes the reader is familiar with the Spotfire environment, has successfully installed Spotfire, and has uploaded and prepared data for analysis. It presents numerous

Abstract Table of Contents Figures Literature Cited Abstract Dynalign is a dynamic programming algorithm for the simultaneous prediction of the lowest?free?energy secondary structure common to two RNA sequences and the alignment of the two

Abstract Table of Contents Figures Literature Cited Abstract The VisANT tool, accessible from any recent Java?enabled browser, is a platform?independent, flexible, Web?enabled program for quick and simple construction, visualization, and a

Abstract Table of Contents Figures Literature Cited Abstract The wide availability and use of DNA microarrays has brought the power of whole?genome functional characterization to a large variety of research environments. Microarrays, howev

Abstract Table of Contents Figures Literature Cited Abstract Non?coding RNA (ncRNA) genes produce a functional RNA product, rather than a translated protein. The range and importance of such genes is only recently apparent, with known ncRN

Abstract Table of Contents Figures Literature Cited Abstract The first part of this unit compares general and locus?specific mutation databases. The second section deals with submitting data. The third part provides guidance for accessing

Abstract Table of Contents Figures Literature Cited Abstract In recent years, several proteomic methodologies have been developed that now make it possible to identify, characterize, and comparatively quantify the relative level of express

Abstract Table of Contents Figures Literature Cited Abstract Expression profiling of biological samples using microarray technologies has proven to be a powerful tool for molecular classification and biomarker identification. Visualization

Abstract Table of Contents Figures Literature Cited Abstract The CorePromoter program is very useful for identification of transcriptional start sites (TSS) and core promoter regions when 5??upstream genomic DNA sequences of human genes ar

Abstract Table of Contents Figures Literature Cited Abstract The Gibbs Motif Sampler (Gibbs) is a software package for discovering conserved elements in biopolymer sequences. This unit describes the basic operation of the Web?based interfa

Abstract Table of Contents Materials Figures Literature Cited Abstract Prediction of molecular function of proteins has become an important task in the genomics era. A wide variety of sequence analysis to

Abstract Table of Contents Figures Literature Cited Abstract The most popular current method of determining protein valence entails the calculation of net charge from amino acid sequence/composition. However, the inaccuracy of that approac

Abstract Table of Contents Materials Figures Literature Cited Abstract This unit describes methods that can accurately determine the genotypes and phenotypes of human complement components C4A and C4B. Sp

Abstract Table of Contents Figures Literature Cited Abstract This unit describes how to use the Parallel Contig Assembly Program (PCAP) to assemble the data produced by a whole?genome shotgun sequencing project. We present a basic protocol

Abstract Table of Contents Figures Literature Cited Abstract With the explosion in sequence data, accurate prediction of protein function has become a vital task in prioritizing experimental investigation. While computationally efficient m

Abstract Table of Contents Figures Literature Cited Abstract This unit describes the use of RasMol, a popular interactive molecular graphics program, for the display of biomolecular structures. The unit begins with a general guide to obtai

Abstract Table of Contents Figures Literature Cited Abstract High?throughput protein?protein interaction data are becoming a foundation for new biological discoveries. A major challenge is to manage, analyze, and model these data. In this

Abstract Table of Contents Figures Literature Cited Abstract Chado is a relational database schema that can be used to manage a wide variety of biological information, including genome annotation, genetic, phenotypic, and expression data.

Abstract Table of Contents Figures Literature Cited Abstract An annotation is any feature that can be tied to genomic sequence, such as an exon, transcript, promoter, or transposable element. As biological knowledge increases, annotations

Abstract Table of Contents Figures Literature Cited Abstract The Biomolecular Interaction Network Database (BIND) comprises data from peer?reviewed literature and direct submissions. BIND's data model was the first of its kind to be peer?r