生物信息学技术

Abstract Table of Contents Materials Figures Literature Cited Abstract Consed is a program for viewing and editing assemblies prepared by the Phrap assembly program. This unit presents a general introduc

Abstract Table of Contents Materials Figures Literature Cited Abstract There is a general agreement that electrostatic interactions play a significant role in the structure and function of biological mole

Abstract Table of Contents Materials Figures Literature Cited Abstract The Database Referencing of Array Genes ONline (DRAGON) database system consists of information derived from publicly available datab

Abstract Table of Contents Figures Literature Cited Abstract Multiple sequence alignment is perhaps the most commonly applied bioinformatics technique. It often leads to fundamental biological insight into sequence?structure?function relat

Abstract Table of Contents Materials Figures Literature Cited Abstract This unit describes predicting the structure of simple transmembrane ??helical bundles. The protocol is based on a global molecular d

Abstract Table of Contents Materials Figures Literature Cited Abstract The computer program FAMS (Full Automatic Modeling System) performs homology modeling of protein structures by means of an algorithm

Abstract Table of Contents Materials Figures Literature Cited Abstract The Basic Protocol describes the use of GrailEXP, the latest version of the gene finding system from Oak Ridge National Laboratory. G

Abstract Table of Contents Materials Figures Literature Cited Abstract In this unit a protocol is described for predicting the structure of simple transmembrane a?helical bundles. The protocol is based on

Abstract Table of Contents Materials Figures Literature Cited Abstract The FASTA package provides a comprehensive set of similarity searching programs, similar to those provided by the BLAST package, and

Abstract Table of Contents Materials Figures Literature Cited Abstract GenMAPP (Gene MicroArray Pathway Profiler) is a free, stand?alone computer program designed for viewing and analyzing gene expression

Abstract Table of Contents Materials Figures Literature Cited Abstract The PEBBLE (Phylogenetics, Evolutionary Biology, and Bioinformatics in a moduLar Environment) application is a relative newcomer to t

Abstract Table of Contents Materials Figures Literature Cited Abstract The Basic Local Alignment Search Tool (BLAST) is one of the widest used and most useful applications in sequence?based bioinformatics

Abstract Table of Contents Literature Cited Abstract Cytokines, chemokines, and growth factors are soluble proteins produced by leukocytes and other cell types, which act as chemical communicators between cells and tissues within the body. These proteins mediate a number of

Abstract Table of Contents Figures Literature Cited Abstract RNAi is a novel genetic tool that is poised to revolutionize the study of genetics and gene networks. Use of this tool requires knowledge of the underlying mechanisms and applica

Abstract Table of Contents Figures Literature Cited Abstract This protocol describes the implementation and interpretation of THEMATICS, a simple computational predictor of functional information for proteins from the three?dimensional str

Abstract Table of Contents Figures Literature Cited Abstract This unit strictly focuses on data preparation within Spotfire. Microarray data exist in a variety of formats, which often depend on the particular array technology and detection

Abstract Table of Contents Figures Literature Cited Abstract Spotfire DecisionSite for Functional Genomics (referred to here as Spotfire) is a powerful data mining and visualization application with use in many disciplines. This unit provi

Abstract Table of Contents Figures Literature Cited Abstract Modern biology is on the verge of officially ushering in a new era in science with the completion of the sequencing of the human genome in April 2003. While often erroneously cal

Abstract Table of Contents Figures Literature Cited Abstract PROWL is a collection of tools for the identification of protein sequences, using input data derived from mass spectrometry. Experimental data from various types of mass spectrom

Abstract Table of Contents Figures Literature Cited Abstract Relational databases are designed to integrate diverse types of information and manage large sets of search results, greatly simplifying genome?scale analyses. Relational databas