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文献和实验Purification of MeCP2-Containing Deacetylase from Xenopus laevis
by the histone deacetylase inhibitor Trichostatin A. In addition, two proteins have been identified, MeCP1 (6 ) and MeCP2 (7 ), that specifically bind to methylated DNA and mediate transcriptional repression. MeCP1 is a relatively uncharacterized complex
MECP2的突变可以导致持续性神经系统退化(neurodegenerative disorder)Rett综合症。这个x-染色体相关综合症(X-linked syndrome)主要在女性身上体现,但相对温和的突变也可以导致男性的智力障碍(mental retardation)。 (Figure 1: Pedigrees of the four families (L36, S49, T33, and T
Purification of the MeCP2/Histone Deacetylase Complex from Xenopus laevis
by the histone deacetylase inhibitor Trichostatin A. In addition, several proteins have been identified that specifically bind to methylated DNA (6-8) . Two of these methyl-DNA binding proteins, MeCP1 and MeCP2 , have been shown to mediate transcriptional










