- ￥1200
- Biorigin
- BN41905R
- 2025年08月14日
- WB,
- Human,Mouse,Rat,Dog,Pig,Cow,Rabbit,Sheep,
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- 详细信息
- 文献和实验
- 技术资料
- 适应物种：
Human,Mouse,Rat,Dog,Pig,Cow,Rabbit,Sheep,
- 应用范围：
WB,
- 抗体英文名：
IGF I
- 规格：
50ul
| 英文名称 | IGF I |
| 中文名称 | 胰岛素样生长因子1抗体 |
| 别 名 | IBP1; IGF 1; IGF I; IGF-1;IGF IA; IGF IB; IGF1; IGFI; IGFIA; Insulin like growth factor 1 (somatomedin C); Full=Insulin-like growth factor I; Insulin Like Growth Factor 1; Insulin like growth factor IA; Insulin like growth factor IB; Mechano growth factor; MGF; Mechano growth factor; MGF; Somatomedia C; Somatomedin C; IGF1_HUMAN. |
| 研究领域 | 细胞生物 发育生物学 信号转导 生长因子和激素 糖尿病 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Rat, (predicted: Mouse, Dog, Pig, Cow, Rabbit, Sheep, ) |
| 产品应用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 7.7/21kDa |
| 细胞定位 | 分泌型蛋白 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IGF I:108-195/195 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 产品介绍 | The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009] Function: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. Subcellular Location: Secreted. DISEASE: Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation. Similarity: Belongs to the insulin family. SWISS: P05019 Gene ID: 3479 Database links: Entrez Gene: 3479 Human Omim: 147440 Human SwissProt: P05019 Human Unigene: 160562 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 胰岛素样生长因子1(IGF-1)是一种生长调节激素，由肝分泌并入血液循环的中性多肽，具有调节生长和代谢、胰岛素样及促细胞分裂的活性。 |
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文献和实验胰岛素样生长因子-1受体（IGF-IR）是一种在质膜中发现的受体酪氨酸激酶，它会介导IGF-1（这是一种参与促进细胞生长和增殖的蛋白质激素）的作用。异常的IGF-1R信号传导与多种癌症有关。 在2010年2月9日刊的Science Signaling的一篇Research Article中，Sehat 等人研究显示，IGF-1可刺激一种叫作SUMOylation的IGF-1R的修饰，这种修饰可使该受体能够被转运到细胞核，并在那里与特别的DNA序列结合以增进标
胰岛素样生长因子检测的临床意义： IGF-I又称为生长调节素C，是细胞生长和分化的主要调节因子之一。多种因素如年龄、性别、营养状态和生长激素的释放都影响血清IGF-I浓度。出生时，其浓度是低的，在儿童和青春期逐渐增长，20岁以后开始下降。这些变化和GH的释放是平行的：GH不足时，血清IGF-I浓度增高。尽管肢端肥大症的临床特征和血清IGF-I浓度并非紧密相关，但测定血清IGF-I在诊断GH不足和肢端肥大症仍是有用的。 营养状态影响IGF-I浓度，它是循环和组织IGFs系统
兔胰岛素样生长因子-1(IGF-1)ELISA试剂盒 说明书
上海西唐生物科技有限公司 021-55229872, 65333639 www.westang.com 兔胰岛素样生长因子-1 ( IGF-1 )ELISA 试剂盒 ( 用于血清、血浆、细胞培养上清液和其它生物体液内 ) 原理 本实验采用双抗体夹心 ABC-ELISA 法。用抗兔 IGF-1 单抗包被于酶标板上，标准品和样品中的 IGF-1与单抗结合，加入生物
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