signal transducers and activators of transduction 6; D12S1644; IL 4 STAT; IL4 STAT; Interleukin 4 Induced; Interleukin 4 Induced Transcription Factor IL4 STAT; Signal Transducer And Activator Of Transcription 6 Interleukin 4 Induced; Signal Transducer And Activator Of Transcription 6 Nirs Variant 1; STAT 6; STAT interleukin4 induced; STAT6B; STAT6C; Transcription factor IL 4 STAT.
研究领域
肿瘤 发育生物学 信号转导 细胞凋亡 转录调节因子 表观遗传学
抗体来源
Rabbit
克隆类型
Monoclonal
克 隆 号
9A7
交叉反应
Human, Mouse,
产品应用
WB=1:500-1000 IHC-P=1:20-200 IHC-F=1:20-200 Flow-Cyt=2ug/Test ICC=1:20-200 IF=1:20-200 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分 子 量
94kDa
细胞定位
细胞核 细胞浆
性 状
Liquid
浓 度
1mg/ml
免 疫 原
Recombinant human STAT6 protein, around 700-800aa:
亚 型
IgG
纯化方法
affinity purified by Protein A
储 存 液
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X (L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins.
Function: Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling.
Subunit: Forms a homodimer or a heterodimer with a related family member. Interacts with NCOA1 via its C-terminal LXXLL motif.
Subcellular Location: Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.
Post-translational modifications: Tyrosine phosphorylated following stimulation by IL-4 and IL-3.
Similarity: Belongs to the transcription factor STAT family. Contains 1 SH2 domain.